Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
نویسندگان
چکیده
منابع مشابه
Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
We previously reported early and extensive loss of astrocytic connexin 43 (Cx43) in acute demyelinating lesions of multiple sclerosis (MS) patients. Because it is widely accepted that autoimmune T cells initiate MS lesions, we hypothesized that infiltrating T cells affect Cx43 expression in astrocytes, which contributes to MS lesion formation. Primary mixed glial cell cultures were prepared fro...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep38387